Timothy Buchman's interpretation of the system dynamics aspects of health and disease (click here)

Man as an industrial palace

Fritz Kahn's wonderful rendition of the human body as and industrial palace (here). A beautiful animation of his designs can be found here.

An Introduction to the Study of Experimental Medicine

Claude Bernard's 1865 major discourse on the scientific method (here)

Organization of physiological homeostasis

Walter Canon's seminal 1929 paper on physiological homeostasis (here).

This is a small, quasi-random, collection of articles and books that I have found inspiring and thought-provoking.I hope you will also enjoy them.

Bounds on sorting

Next time you call Bill Gates a "college drop-out" consider this: In this 1979 paper he discussed pancake sorting algorithm (here) that took 30 years to beat (here) !

On computable numbers

Alan Turing's seminal 1936 paper, likely define the concept of computing using algortihms (here)

Asynchronous & Distributed Computing

Bertsekas-Tsitsiklis's 1986 paper on asynchronous computation (here); Bertsekas's outstanding textbook o districtued computing (here) and ten simple rules on mathematical wirting (here)

Method for node ranking in a linked data base

Lary Page's patent that likely started Google (here)

The practice of progamming

Learning from the best. Brian Kernighan's "must read" book of computer programming (here)

Searching in large spaces

Sergey Bryn's 1995 paper on searching large metric spaces (here)

Computational ecologies

Bernaddo Huberman's 1989 paper on non optimal strategies (here) and 1993 paper on emerging computational ecologies (here)

The central dogma of molecular biology

Francis Crick's 1970 Nature paper on the detailed residue-by-residue transfer of sequential information (here)

The art of scientific programming

Edsger Dijsktra's 1971 beautiful introduction to programming (here)

Reflections on mentorship

Michael Joyner, MD, shares his views on the art of mentoring in this very enganging video (here)

Ten questions about Systems Biology

Michael Joyner, MD, attempts to move systems biology from the cell to the host. Worth reading ! (here)

Metabolic syndrome and robustness trade-offs. John Doyle's work on robustness. I know that he is not the "corresponding" author, but his work on trade-off is really pioneeting (here)

The nature of mathematical modeling. Neil Gershenfeld's very nice textbook about the kinds of mathematical models and their usefulness (here)

Allostasis: A new paradigm to explain arousal pathology. Peter Sterling's introduction of the concept of "allostasis" (here)

All models are wrong: Relflections on becoming a systems scientist. J.D. Sterman's paper on his talk delivered in 2002 upon receiving the J.W. Forrester Award (here)

Delivered in the fall of 1973 and collectively titled “The Unanswered Question,” Bernstein’s lectures covered a lot of terrain, touching on poetry, linguistics, philosophy and physics (here)

The information highway

Gianni Astarita's 1996 prophetic words on how more information does not necessarily increase knowledge (here)